ED treatment enters the era of topical application｜Clinic-developed cream incorporating stem cell supernatant

Let’s say goodbye to quick-fix ED treatments

For those struggling with ED treatment

These are concerns shared by many middle-aged and older men. Conventional treatments like Viagra have only provided temporary solutions. That’s where exstem comes in. With the power of stem cell supernatant exosomes, it can lead to a fundamental treatment for ED.

Three benefits of using exstem

Feedback from users

According to a survey conducted with 24 exstem users, the feedback was as follows:
・More sustained erections: 62.5% (15/24 users)
・Increased frequency of morning erections: 70.8% (17/24 users)
・Enhanced erection hardness: 75% (18/24 users)

In addition, many users shared responses such as:
・During intercourse, my wife happily remarked, “You’re firmer now.”
・The frequency of morning erections clearly increased—from once or twice a week to nearly every day, leaving me feeling energized every morning.
・I can now maintain an erection during intercourse (previously, I couldn’t sustain it when changing positions).

Enhancing your erection quality with exstem can help you recapture the vigor and masculinity you experienced in your twenties.

Presented at the Annual Meeting of the Japanese Anti-Aging Medicine Society

Frequently Asked Questions

Q. Are there any side effects？

A. This product is not a pharmaceutical, so tests for side effects have not been conducted; however, there have been reports of cases where itching and other symptoms occur. Additionally, allergic reactions to some of its ingredients have been observed. If you notice any abnormalities while using the product, please discontinue use and consult a dermatologist or similar specialist.

Q.How is quality control performed?

A.The product undergoes the following final checks to enhance safety:
・Sterility tests (using rapid microbial testing method/gas measurement method)
・Patch tests
・Mycoplasma tests (using the NAT method)
・Endotoxin tests (using the endpoint colorimetric method)
・Virus tests (for human viruses)
・Infectious disease tests via blood tests (performed at the time of stem cell collection)

Q. How is the manufacturing environment managed?

A.The manufacturing environment is managed in a clinic-associated cell culture processing facility (CPC), where sterilization is carried out using a Class 100 clean room and filtration. The Class 100 standard means an environment in which there are no more than 100 particles (0.5 μm or larger) per cubic foot of air (roughly equivalent to a cube of about 30 cm on each side). In Japan, this represents the highest level for a factory clean room, exceeding by two classes the standards required for pharmaceuticals, food, and similar products.

Q.How are the stem cell donors selected?

A.Donors are selected exclusively from healthy Japanese individuals who meet the following examination criteria and conditions:

• Multiple virus and bacterial tests (blood tests) are performed several times at monthly intervals.
• Source cell types and corresponding age conditions:
 - Deciduous teeth: ages 6 to 8 years
 - Adipose tissue: in their 20s or 30s
 - Wharton’s jelly: in their 20s or 30s

In cases where tests are not passed, the procedures call for disposal in accordance with established protocols. Additionally, a serum-free culture medium specifically designed for adipose-derived stem cells (ADSCs) is used for cultivation.

Q.What type of stem cell culture supernatant is used?

A.This product contains three types of stem cell-derived culture supernatants:

• Human adipose-derived stem cell conditioned medium
• Human dental pulp cell conditioned medium
• Human cytokine mesenchymal stem cell exosomes

These have been carefully selected for their recognized high safety and effectiveness, and are manufactured under strict quality control.

Q.How is safety ensured during cultivation?

A.We use a serum-free medium specifically designed for the cultivation of adipose-derived stem cells (ADSCs). This medium has the following characteristics:
・It does not contain phenol red, thereby eliminating any estrogen-like effects.
・It is free of xenogeneic animal components (xeno-free), which helps avoid the risk of infections from animal-derived materials.
・It does not contain phenol red, thereby eliminating any estrogen-like effects.

Q.What effects have been confirmed?

A.In a study conducted by Dr. Amano, the growth factors contained in a cream formulated with human stem cell-conditioned medium were found to improve vascular endothelial function and increase blood flow, showing potential in alleviating symptoms of ED and male menopause.

Subjects: 10 healthy males (average age approximately 43 years).

Usage: Applied twice daily to the genital area and scrotum for 30 days.

Evaluation methods: Effects were measured using the International Index of Erectile Function (IIEF-5), the Aging Males’ Symptoms Scale (AMS), and the Erection Hardness Score (EHS).

Results:
1. IIEF-5 scores significantly improved (from 11.8 to 17.2, P < 0.001)
2. AMS scores also improved (from 46.3 to 37.6, P < 0.001)
3. The EHS did not reach statistical significance, but an improving trend was observed.
4. Participants reported increased morning erections, improved endurance during sexual intercourse, and reduced fatigue.

Article：https://www.scirp.org/journal/paperinformation?paperid=134628

Q. What precautions should be taken during use?

A.Please avoid engaging in oral sex after using this product. For vaginal insertion, use a condom as a precaution. The active ingredients are absorbed within approximately 30 minutes, and washing after around 2 hours is considered acceptable. Additionally, the formulation is designed for 1 to 2 applications per day, so please avoid excessive use.